Retatrutide (20mg)
Table of Contents
Quickstart Highlights
Retatrutide 20mg dosage protocol is designed to support metabolic improvements and assist in weight management through once-weekly subcutaneous injections.
- Typical starting dose between 0.5 – 2 mg per week
- Once-weekly injection schedule for ease of use
- Gradual titration to manage side effects and improve tolerance
- Reconstitute to a practical concentration for accurate dosing
- Store lyophilized in the freezer; reconstituted in the refrigerator
Dosing & Reconstitution Guide
Educational guide for reconstitution and dosing protocol
Standard / Gradual Approach (3 mL ≈ 6.67 mg/mL)
| Phase | Weekly Dose (mg) | Approx. Units |
|---|---|---|
| Weeks 1–4 | 0.5 mg | ~7.5 units |
| Weeks 5–8 | 1 mg | 15 units |
| Weeks 9–12 | 2 mg | 30 units |
| Weeks 13–16 (Optional) | 4 mg | 60 units |
Reconstitute with 3 mL of bacteriostatic water to create a ~6.67 mg/mL solution.
Note: 0.5 mg yields ~7.5 units, which is under 10 units. Consider using smaller insulin syringes for better accuracy at very low doses.
- Draw 3.0 mL of bacteriostatic water into a sterile syringe.
- Inject the water slowly along the vial wall to reduce foam.
- Gently swirl—avoid vigorous shaking.
- Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Advanced / Aggressive Approach (2 mL = 10 mg/mL)
| Phase | Weekly Dose (mg) | Approx. Units |
|---|---|---|
| Weeks 1–4 | 2 mg | 20 units |
| Weeks 5–8 | 4 mg | 40 units |
| Weeks 9–12 | 8 mg | 80 units |
| Weeks 13–16 (Optional) | 12 mg | 120 units |
Recommended for higher doses (8–12 mg weekly). Reconstitute with 2 mL to create a 10 mg/mL solution.
Note: Doses of 12 mg or more require ≥1.2 mL; one vial can accommodate the full volume, but you may need to split into multiple injections if using standard 1 mL insulin syringes.
- Draw 2.0 mL of bacteriostatic water into a sterile syringe.
- Slowly inject the water to minimize foam.
- Gently roll/swirl the vial—no vigorous shaking.
- Store the reconstituted solution at 2–8 °C (refrigerator), protected from light.
Protocol Overview
A concise summary of this once-weekly regimen.
- Goal : Promote weight loss and metabolic improvement
- Schedule : Weekly subcutaneous injections for 8–12 weeks (or longer)
- Dose Range : 0.5 mg to 2 mg weekly, with potential escalation up to 12 mg
- Reconstitution : Up to 3 mL to maintain practical “units” for injections
- Storage : Keep lyophilized vials frozen; refrigerate after reconstitution
Dosing Protocol
Suggested once-weekly injection approach for effective titration.
- Weekly Dose : Start at 0.5 mg; gradually increase as tolerated
- Frequency : Inject once per week subcutaneously
- Cycle Length : 8–12 weeks (extend as needed for maintenance)
- Maximum Dose : Can escalate to 12 mg weekly, depending on goals
- Timing : Any time of day; consistency is key
Storage Instructions
Proper storage ensures peptide integrity.
- Lyophilized : Freeze until mixing (−20°C)
- Reconstituted : Refrigerate at 2–8°C
- Use within 30 days of reconstitution
- Avoid repeated freeze-thaw cycles
Suppilies Needed
Ensure you have these on hand for an 8–16 week cycle.
- Peptide Vials :
-
- 8 wks ≈ 1 vial
- 12 wks ≈ 2 vials
- 16 wks ≈ 2–3 vials (More if planning higher doses)
- Insulin Syringes :
-
- 8 wks ≈ 8
- 12 wks ≈ 12
- 16 wks ≈ 16
- Bacteriostatic Water : 1× 30ml
- Alcohol Swabs: 1 box
Important Notes
Practical tips to enhance safety and efficacy.
- Always use new, sterile insulin syringes & rotate injection sites.
- Maintain consistency; follow the planned schedule for reliable results.
- Observe for adverse reactions; consult a professional if concerns arise.
- Track progress throughout the protocol, adjusting dosage as recommended.
How This Works
Retatrutide is a multi-receptor agonist that helps regulate appetite and metabolism.
- Hormone Pathways : Activates GLP-1, GIP, and glucagon receptors
- Metabolic Support : Assists in lowering body weight and improving metabolic markers
- Targets multiple pathways to enhance energy balance and satiety
Potential Benefits & Side Effects
Most users observe enhanced weight management, though results can vary.
- Supports healthier metabolic function
- Aids in body weight reduction strategies
- Possible mild side effects include nausea, dizziness, or GI discomfort
- Rarely, injection-site irritation or headaches could occur
Lifestyle Factors
Complementary strategies for maximum benefit.
- Adopt a nutrient-dense, protein-rich diet
- Incorporate regular exercise and prioritize recovery
- Manage stress levels and aim for adequate sleep
Injection Technique
Simple guidelines for safe daily injections.
- Clean vial rubber stopper & injection site with alcohol swabs
- Insert needle at a 45–90° angle into subcutaneous tissue
- Inject slowly & rotate sites (abdomen, thigh, etc.)
Recommended Source
We recommend Go Alpha Labs for high-purity Retatrutide (20mg).
Why Go Alpha Labs?
- Verifies ≥99% purity through independent lab testing
- Trusted by researchers seeking reliable results
- Follows rigorous manufacturing standards for consistent quality
Important Note:
This guide is for educational purposes only. Always consult a qualified healthcare provider before starting or modifying any therapy.
References:
| Source | Link |
|---|---|
| PubMed Central (PMC) – Phase 2 obesity trial correspondence | View Source |
| New England Journal of Medicine – Triple-hormone receptor agonist trial | View Source |
| Nature Medicine – Phase 2a NAFLD substudy results | View Source |
| NCBI Bookshelf – GLP-1 RA pregnancy & breastfeeding guidance | View Source |
| AACE Clinical Case Reports – Case report: GLP-1 agonist pancreatitis | View Source |
| Calhoun.edu – Reconstitution of Solutions overview | View Source |
| Sigma Aldrich – Handling and storage guidelines | View Source |
| Health Canada Resource – DHPP official guidance document | View Source |
| The Lancet – Retatrutide obesity study | View Source |